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Structure (Figure 2). Although the overall structural difference between WT and 2SHP was small, we used our WT structure as the reference for comparison with the mutant structures to exclude any potential structural changes induced by the three mutations and the detergent molecule (CTAB) in 2SHP.D61GIn the WT structure, Asp61 was located on the surface of the N-SH2 domain. The side chain of Asp61
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E targets, depot effect, high encapsulation and transport [38] efficiency, targeted deliveryE targets, depot effect, high encapsulation and transport [38] efficiency, targeted delivery . Polymeric nanoparticles (NPs) consist of polymeric colloidal nanoparticles prepared from biodegradable and biocompatible, natural or synthetic polymers, ranging in sizes from 10 nm to 1 m. A wide variety of
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Icity of the liposomal surface, and/or by encapsulating additional adjuvantsIcity of the liposomal surface, and/or by encapsulating additional adjuvants ("conventional" and second-generation liposomes, the [44-46] stealth technology ). Since liposomes were first described in 1960, these nanoparticulate carriers were investigated for various purposes - including industrial, pharmaceutical, cl
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Bers were as follows: (DnaK)- 32-(DnaJ2) (184 kDa), Fractions 25 and 26; DnaK- 32 (101 kDa) and (DnaJ2)- 32 (114 kDa), Fractions 27 and 28; and DnaJ2 (82 kDa), Fractions 28 ?0. Because DnaJ was eluted over a wide range from the void volume to Fraction 30 (perhaps due to self-aggregation), the fraction numbers corresponding to a free DnaJ dimer (DnaJ2) were not precisely determined. Other Methods--
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Osclerotic plaque volume in the superficial femoral artery when compared to those already treated with statin given ezetimibe. Reverse vessel wall remodeling was noted among PAD patients newly treated with statins compared to those with ezetimibe added to preexisting statin therapy. Thus the degree and/or mechanism of LDL lowering rather than the final LDL achieved may be important in halting athe
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Osclerotic plaque volume in the superficial femoral artery when compared to those already treated with statin given ezetimibe. Reverse vessel wall remodeling was noted among PAD patients newly treated with statins compared to those with ezetimibe added to preexisting statin therapy. Thus the degree and/or mechanism of LDL lowering rather than the final LDL achieved may be important in halting athe
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Ne et al., 2008; McAdams, 1988, 1993), defined as `purposeful action for the well-being of future generations, and the emergence of person goal and agency' (Creed et al., 2014 113), to make a conceptual contribution towards the burgeoning literature on narrative identities. We demonstrate that thr.Ne et al., 2008; McAdams, 1988, 1993), defined as `purposeful action for the well-being of future gen