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S from MARCO-/- and SR-AI/II-/- mice, they demonstrate marked decreased binding and phagocytosis of these particles compared to primary AMs from wild type mice (Fig. 6A and Fig. 7A and Fig. 7B). The results confirm that MARCO and SR-AI/II receptors on alveolar macrophages play critical roles in uptake of unopsonized environmental particles and bacteria. Moreover, the reduced, but still demonstrabl
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